Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current I(Na) by Lamotrigine; A Potential for Acquired Arrythmias

Lamotrigine is widely prescribed to treat bipolar neurological disorder and epilepsy. It exerts its antiepileptic action by blocking voltage-gated sodium channels in neurons. Recently, the US Food and Drug Administration issued a warning on the use of Lamotrigine after observations of conduction ano...

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Detalles Bibliográficos
Autores principales: Contreras Vite, Juan Antonio, Vega Valle, Carlos, Biekeu Mbem, Happi, Boivin, Sarah-Maude, Dumaine, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609666/
https://www.ncbi.nlm.nih.gov/pubmed/36297320
http://dx.doi.org/10.3390/ph15101208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609666/
https://www.ncbi.nlm.nih.gov/pubmed/36297320
http://dx.doi.org/10.3390/ph15101208

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