Alternative Methotrexate Oral Formulation: Enhanced Aqueous Solubility, Bioavailability, Photostability, and Permeability

The poor aqueous solubility and/or permeability and thereby limited bioavailability largely restricts the pharmaco-therapeutic implications of potent anticancer drugs such as methotrexate (MTX). Furthermore, MTX’s inherently unstable nature makes it difficult to develop a viable oral formulation. In...

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Detalles Bibliográficos
Autores principales: Giri, Bhupendra Raj, Yang, Hyun Seok, Song, Im-Sook, Choi, Han-Gon, Cho, Jung Hyun, Kim, Dong Wuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609692/
https://www.ncbi.nlm.nih.gov/pubmed/36297508
http://dx.doi.org/10.3390/pharmaceutics14102073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609692/
https://www.ncbi.nlm.nih.gov/pubmed/36297508
http://dx.doi.org/10.3390/pharmaceutics14102073

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