Radiosynthesis and Preclinical Evaluation of an (18)F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A)

The cyclic nucleotide phosphodiesterase 2A is an intracellular enzyme which hydrolyzes the secondary messengers cAMP and cGMP and therefore plays an important role in signaling cascades. A high expression in distinct brain areas as well as in cancer cells makes PDE2A an interesting therapeutic and d...

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Detalles Bibliográficos
Autores principales: Wenzel, Barbara, Fritzsche, Stefan R., Toussaint, Magali, Briel, Detlef, Kopka, Klaus, Brust, Peter, Scheunemann, Matthias, Deuther-Conrad, Winnie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609767/
https://www.ncbi.nlm.nih.gov/pubmed/36297384
http://dx.doi.org/10.3390/ph15101272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609767/
https://www.ncbi.nlm.nih.gov/pubmed/36297384
http://dx.doi.org/10.3390/ph15101272

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