Serum Bile Acid Profiling and Mixed Model Analysis Reveal Biomarkers Associated with Pruritus Reduction in Maralixibat-Treated Patients with BSEP Deficiency

Progressive familial intrahepatic cholestasis (PFIC) is a debilitating disease manifest by severe cholestasis, intractable pruritus and growth delay that ultimately leads to liver failure or transplantation. Maralixibat (MRX) was recently approved for the treatment of cholestatic pruritus in patient...

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Detalles Bibliográficos
Autores principales: Zhao, Xueheng, Zhang, Wujuan, Vig, Pamela, Kostrub, Cory, Setchell, Kenneth D. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609791/
https://www.ncbi.nlm.nih.gov/pubmed/36295854
http://dx.doi.org/10.3390/metabo12100952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609791/
https://www.ncbi.nlm.nih.gov/pubmed/36295854
http://dx.doi.org/10.3390/metabo12100952

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