Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening

Transient Receptor Potential Melastatin 8 (TRPM8) from the melastatin TRP channel subfamily is a non-selective Ca(2+)-permeable ion channel with multimodal gating which can be activated by low temperatures and cooling compounds, such as menthol and icilin. Different conditions such as neuropathic pa...

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Detalles Bibliográficos
Autores principales: Jahanfar, Farhad, Sadofsky, Laura, Morice, Alyn, D’Amico, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609861/
https://www.ncbi.nlm.nih.gov/pubmed/36295712
http://dx.doi.org/10.3390/membranes12100954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609861/
https://www.ncbi.nlm.nih.gov/pubmed/36295712
http://dx.doi.org/10.3390/membranes12100954

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