Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats

The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of (1)H and (13)C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in Wistar rats...

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Detalles Bibliográficos
Autores principales: Monteiro, Noemi Oliveira, Monteiro, Theresa de Moura, Nogueira, Thalya Soares R., Cesar, Jacqueline Rodrigues, Nascimento, Lara Pessanha S., Campelo, Karoline Azerêdo, Silveira, Graziela Rangel, Antunes, Fernanda, de Oliveira, Daniela Barros, de Carvalho Junior, Almir Ribeiro, Braz-Filho, Raimundo, Vieira, Ivo José Curcino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609921/
https://www.ncbi.nlm.nih.gov/pubmed/36296487
http://dx.doi.org/10.3390/molecules27206895
Descripción
Sumario:The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of (1)H and (13)C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in Wistar rats. This alkaloid significantly reduced (p < 0.05) the systolic, median, and diastolic blood pressures of rodents, without causing motor incoordination and imbalance in the rotarod test. The results indicate that the alkaloid Aspidocarpine exerts its antihypertensive activity without causing sedation or the impairment of motor functions.

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