Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats

The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of (1)H and (13)C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in Wistar rats...

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Autores principales: Monteiro, Noemi Oliveira, Monteiro, Theresa de Moura, Nogueira, Thalya Soares R., Cesar, Jacqueline Rodrigues, Nascimento, Lara Pessanha S., Campelo, Karoline Azerêdo, Silveira, Graziela Rangel, Antunes, Fernanda, de Oliveira, Daniela Barros, de Carvalho Junior, Almir Ribeiro, Braz-Filho, Raimundo, Vieira, Ivo José Curcino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609921/
https://www.ncbi.nlm.nih.gov/pubmed/36296487
http://dx.doi.org/10.3390/molecules27206895
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author Monteiro, Noemi Oliveira
Monteiro, Theresa de Moura
Nogueira, Thalya Soares R.
Cesar, Jacqueline Rodrigues
Nascimento, Lara Pessanha S.
Campelo, Karoline Azerêdo
Silveira, Graziela Rangel
Antunes, Fernanda
de Oliveira, Daniela Barros
de Carvalho Junior, Almir Ribeiro
Braz-Filho, Raimundo
Vieira, Ivo José Curcino
author_facet Monteiro, Noemi Oliveira
Monteiro, Theresa de Moura
Nogueira, Thalya Soares R.
Cesar, Jacqueline Rodrigues
Nascimento, Lara Pessanha S.
Campelo, Karoline Azerêdo
Silveira, Graziela Rangel
Antunes, Fernanda
de Oliveira, Daniela Barros
de Carvalho Junior, Almir Ribeiro
Braz-Filho, Raimundo
Vieira, Ivo José Curcino
author_sort Monteiro, Noemi Oliveira
collection PubMed
description The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of (1)H and (13)C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in Wistar rats. This alkaloid significantly reduced (p < 0.05) the systolic, median, and diastolic blood pressures of rodents, without causing motor incoordination and imbalance in the rotarod test. The results indicate that the alkaloid Aspidocarpine exerts its antihypertensive activity without causing sedation or the impairment of motor functions.
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spelling pubmed-96099212022-10-28 Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats Monteiro, Noemi Oliveira Monteiro, Theresa de Moura Nogueira, Thalya Soares R. Cesar, Jacqueline Rodrigues Nascimento, Lara Pessanha S. Campelo, Karoline Azerêdo Silveira, Graziela Rangel Antunes, Fernanda de Oliveira, Daniela Barros de Carvalho Junior, Almir Ribeiro Braz-Filho, Raimundo Vieira, Ivo José Curcino Molecules Article The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of (1)H and (13)C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in Wistar rats. This alkaloid significantly reduced (p < 0.05) the systolic, median, and diastolic blood pressures of rodents, without causing motor incoordination and imbalance in the rotarod test. The results indicate that the alkaloid Aspidocarpine exerts its antihypertensive activity without causing sedation or the impairment of motor functions. MDPI 2022-10-14 /pmc/articles/PMC9609921/ /pubmed/36296487 http://dx.doi.org/10.3390/molecules27206895 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Monteiro, Noemi Oliveira
Monteiro, Theresa de Moura
Nogueira, Thalya Soares R.
Cesar, Jacqueline Rodrigues
Nascimento, Lara Pessanha S.
Campelo, Karoline Azerêdo
Silveira, Graziela Rangel
Antunes, Fernanda
de Oliveira, Daniela Barros
de Carvalho Junior, Almir Ribeiro
Braz-Filho, Raimundo
Vieira, Ivo José Curcino
Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats
title Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats
title_full Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats
title_fullStr Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats
title_full_unstemmed Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats
title_short Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats
title_sort antihypertensive activity of the alkaloid aspidocarpine in normotensive wistar rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609921/
https://www.ncbi.nlm.nih.gov/pubmed/36296487
http://dx.doi.org/10.3390/molecules27206895
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