Polymorphism of Drug Transporters, Rather Than Metabolizing Enzymes, Conditions the Pharmacokinetics of Rasagiline

Rasagiline is a selective and irreversible inhibitor of monoamine oxidase type B with neuroprotective effect, indicated for the management of Parkinson’s disease. The aim of this work was to evaluate the impact of seven CYP1A2 alleles and of 120 additional variants located in other CYP enzymes (e.g....

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Detalles Bibliográficos
Autores principales: Zubiaur, Pablo, Matas, Miriam, Martín-Vílchez, Samuel, Soria-Chacartegui, Paula, Villapalos-García, Gonzalo, Figueiredo-Tor, Laura, Calleja, Sofía, Navares-Gómez, Marcos, de Miguel, Alejandro, Novalbos, Jesús, Mejía-Abril, Gina, Luquero-Bueno, Sergio, Román, Manuel, Ochoa, Dolores, Abad-Santos, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610285/
https://www.ncbi.nlm.nih.gov/pubmed/36297437
http://dx.doi.org/10.3390/pharmaceutics14102001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610285/
https://www.ncbi.nlm.nih.gov/pubmed/36297437
http://dx.doi.org/10.3390/pharmaceutics14102001

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