Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack

Vaccines targeting HIV-1’s gp160 spike protein are stymied by high viral mutation rates and structural chicanery. gp160’s membrane-proximal external region (MPER) is the target of naturally arising broadly neutralizing antibodies (bnAbs), yet MPER-based vaccines fail to generate bnAbs. Here, nanodis...

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Detalles Bibliográficos
Autores principales: Yang, Shuang, Hiotis, Giorgos, Wang, Yi, Chen, Junjian, Wang, Jia-huai, Kim, Mikyung, Reinherz, Ellis L., Walz, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610346/
https://www.ncbi.nlm.nih.gov/pubmed/36302771
http://dx.doi.org/10.1038/s41467-022-34008-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610346/
https://www.ncbi.nlm.nih.gov/pubmed/36302771
http://dx.doi.org/10.1038/s41467-022-34008-y

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