Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria

Changes in the phenylalanine (PHE)/tyrosine (TYR) pathway metabolites before and during homogentisic acid (HGA)-lowering by nitisinone in the Suitability of Nitisinone in Alkaptonuria (AKU) 2 (SONIA 2) study enabled the magnitude of the flux in the pathway to be examined. SONIA 2 was a 48-month rand...

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Detalles Bibliográficos
Autores principales: Ranganath, Lakshminarayan R., Hughes, Andrew T., Davison, Andrew S., Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P., Bou-Gharios, George, Gallagher, James A., Milan, Anna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610527/
https://www.ncbi.nlm.nih.gov/pubmed/36295821
http://dx.doi.org/10.3390/metabo12100920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610527/
https://www.ncbi.nlm.nih.gov/pubmed/36295821
http://dx.doi.org/10.3390/metabo12100920

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