Doxorubicin-Loaded Polymeric Micelles Conjugated with CKR- and EVQ-FLT3 Peptides for Cytotoxicity in Leukemic Stem Cells

Doxorubicin (Dox) is the standard chemotherapeutic agent for acute myeloblastic leukemia (AML) treatment. However, 40% of Dox-treated AML cases relapsed due to the presence of leukemic stem cells (LSCs). Thus, poloxamer 407 and CKR- and EVQ-FLT3 peptides were used to formulate Dox-micelles (DMs) and...

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Detalles Bibliográficos
Autores principales: Chueahongthong, Fah, Tima, Singkome, Chiampanichayakul, Sawitree, Dejkriengkraikul, Pornngarm, Okonogi, Siriporn, Sasarom, Mathurada, Rodwattanagul, Soraya, Berkland, Cory, Anuchapreeda, Songyot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610626/
https://www.ncbi.nlm.nih.gov/pubmed/36297550
http://dx.doi.org/10.3390/pharmaceutics14102115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610626/
https://www.ncbi.nlm.nih.gov/pubmed/36297550
http://dx.doi.org/10.3390/pharmaceutics14102115

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