Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways

Opioid receptors (ORs) are classified into three types (μ, δ, and κ), and opioid analgesics are mainly mediated by μOR activation; however, their use is sometimes restricted by unfavorable effects. The selective κOR agonist nalfurafine was initially developed as an analgesic, but its indication was...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Masahiro, Miyano, Kanako, Hirayama, Shigeto, Karasawa, Yusuke, Ohshima, Kaori, Uezono, Eiko, Komatsu, Akane, Nonaka, Miki, Fujii, Hideaki, Yamaguchi, Keisuke, Iseki, Masako, Hayashida, Masakazu, Uezono, Yasuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611050/
https://www.ncbi.nlm.nih.gov/pubmed/36296658
http://dx.doi.org/10.3390/molecules27207065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611050/
https://www.ncbi.nlm.nih.gov/pubmed/36296658
http://dx.doi.org/10.3390/molecules27207065

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