Paeonol Protects against Methotrexate Hepatotoxicity by Repressing Oxidative Stress, Inflammation, and Apoptosis—The Role of Drug Efflux Transporters

Methotrexate (MTX) is an effective chemotherapeutic agent against a wide range of tumors and autoimmune diseases; however, hepatotoxicity limits its clinical use. Oxidative stress and inflammation have been implicated in the pathogenesis of MTX-induced hepatotoxicity. Paeonol is a natural phenolic c...

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Detalles Bibliográficos
Autores principales: Morsy, Mohamed A., Abdel-Latif, Rania, Hafez, Sara Mohamed Naguib Abdel, Kandeel, Mahmoud, Abdel-Gaber, Seham A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611069/
https://www.ncbi.nlm.nih.gov/pubmed/36297408
http://dx.doi.org/10.3390/ph15101296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611069/
https://www.ncbi.nlm.nih.gov/pubmed/36297408
http://dx.doi.org/10.3390/ph15101296

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