Comparative Pharmacokinetics of a Dual Inhibitor of HIV-1, NBD-14189, in Rats and Dogs with a Proof-of-Concept Evaluation of Antiviral Potency in SCID-hu Mouse Model

We earlier reported substantial progress in designing gp120 antagonists. Notably, we discovered that NBD-14189 is not only the most active gp120 antagonist but also shows antiviral activity against HIV-1 Reverse Transcriptase (RT). We also confirmed its binding to HIV-1 RT by X-ray crystallography....

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Detalles Bibliográficos
Autores principales: Stoddart, Cheryl A., Curreli, Francesca, Horrigan, Stephen, Altieri, Andrea, Kurkin, Alexander V., Debnath, Asim K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611370/
https://www.ncbi.nlm.nih.gov/pubmed/36298823
http://dx.doi.org/10.3390/v14102268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611370/
https://www.ncbi.nlm.nih.gov/pubmed/36298823
http://dx.doi.org/10.3390/v14102268

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