Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria

Metabolomic analyses in alkaptonuria (AKU) have recently revealed alternative pathways in phenylalanine-tyrosine (phe-tyr) metabolism from biotransformation of homogentisic acid (HGA), the active molecule in this disease. The aim of this research was to study the phe-tyr metabolic pathway and whethe...

Descripción completa

Detalles Bibliográficos
Autores principales: Norman, Brendan P., Davison, Andrew S., Hickton, Bryony, Ross, Gordon A., Milan, Anna M., Hughes, Andrew T., Wilson, Peter J. M., Sutherland, Hazel, Hughes, Juliette H., Roberts, Norman B., Bou-Gharios, George, Gallagher, James A., Ranganath, Lakshminarayan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611790/
https://www.ncbi.nlm.nih.gov/pubmed/36295829
http://dx.doi.org/10.3390/metabo12100927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611790/
https://www.ncbi.nlm.nih.gov/pubmed/36295829
http://dx.doi.org/10.3390/metabo12100927

Ejemplares similares