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Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria

Metabolomic analyses in alkaptonuria (AKU) have recently revealed alternative pathways in phenylalanine-tyrosine (phe-tyr) metabolism from biotransformation of homogentisic acid (HGA), the active molecule in this disease. The aim of this research was to study the phe-tyr metabolic pathway and whethe...

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Detalles Bibliográficos
Autores principales:	Norman, Brendan P., Davison, Andrew S., Hickton, Bryony, Ross, Gordon A., Milan, Anna M., Hughes, Andrew T., Wilson, Peter J. M., Sutherland, Hazel, Hughes, Juliette H., Roberts, Norman B., Bou-Gharios, George, Gallagher, James A., Ranganath, Lakshminarayan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611790/ https://www.ncbi.nlm.nih.gov/pubmed/36295829 http://dx.doi.org/10.3390/metabo12100927

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