Implementation and Cross-Validation of a Pharmacokinetic Model for Precision Dosing of Busulfan in Hematopoietic Stem Cell Transplanted Children

Busulfan, a drug used in conditioning prior to hematopoietic stem cell transplantation (HSCT) in children, has a narrow therapeutic margin. The model-informed precision dosing (MIPD) of busulfan is desirable, but there is a lack of validated tools. The objective of this study was to implement and cr...

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Detalles Bibliográficos
Autores principales: Goutelle, Sylvain, Thoma, Yann, Buffet, Roxane, Philippe, Michael, Buclin, Thierry, Guidi, Monia, Csajka, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611936/
https://www.ncbi.nlm.nih.gov/pubmed/36297541
http://dx.doi.org/10.3390/pharmaceutics14102107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611936/
https://www.ncbi.nlm.nih.gov/pubmed/36297541
http://dx.doi.org/10.3390/pharmaceutics14102107

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