Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity

Immune cell state alterations rewire HIV-1 gene expression, thereby influencing viral latency and reactivation, but the mechanisms are still unfolding. Here, using a screen approach on CD4(+) T cell models of HIV-1 latency, we revealed Small Molecule Reactivators (SMOREs) with unique chemistries alt...

Descripción completa

Detalles Bibliográficos
Autores principales: Cruz-Lorenzo, Emily, Ramirez, Nora-Guadalupe P., Lee, Jeon, Pandhe, Sonali, Wang, Lei, Hernandez-Doria, Juan, Spivak, Adam M., Planelles, Vicente, Petersen, Tianna, Jain, Mamta K., Martinez, Elisabeth D., D’Orso, Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612055/
https://www.ncbi.nlm.nih.gov/pubmed/36298843
http://dx.doi.org/10.3390/v14102288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612055/
https://www.ncbi.nlm.nih.gov/pubmed/36298843
http://dx.doi.org/10.3390/v14102288

Ejemplares similares