Immunogenicity, Safety, and Anti-Viral Efficacy of a Subunit SARS-CoV-2 Vaccine Candidate in Captive Black-Footed Ferrets (Mustela nigripes) and Their Susceptibility to Viral Challenge

A preliminary vaccination trial against the emergent pathogen, SARS-CoV-2, was completed in captive black-footed ferrets (Mustela nigripes; BFF) to assess safety, immunogenicity, and anti-viral efficacy. Vaccination and boosting of 15 BFF with purified SARS-CoV-2 S1 subunit protein produced a nearly...

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Detalles Bibliográficos
Autores principales: Leon, Ariel E., Garelle, Della, Hartwig, Airn, Falendysz, Elizabeth A., Ip, Hon S., Lankton, Julia S., Tretten, Tyler N., Spraker, Terry R., Bowen, Richard, Rocke, Tonie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612080/
https://www.ncbi.nlm.nih.gov/pubmed/36298743
http://dx.doi.org/10.3390/v14102188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612080/
https://www.ncbi.nlm.nih.gov/pubmed/36298743
http://dx.doi.org/10.3390/v14102188

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