SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse Model

Small animal models that accurately model pathogenesis of SARS-CoV-2 variants are required for ongoing research efforts. We modified our human immune system mouse model to support replication of SARS-CoV-2 by implantation of human lung tissue into the mice to create TKO-BLT-Lung (L) mice and compare...

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Detalles Bibliográficos
Autores principales: Di, Yunyun, Lew, Jocelyne, Goncin, Una, Radomska, Anna, Rout, Saurav S., Gray, Bridget E. T., Machtaler, Steven, Falzarano, Darryl, Lavender, Kerry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612296/
https://www.ncbi.nlm.nih.gov/pubmed/36298826
http://dx.doi.org/10.3390/v14102272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612296/
https://www.ncbi.nlm.nih.gov/pubmed/36298826
http://dx.doi.org/10.3390/v14102272

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