Chitosan/Cyclodextrin Nanospheres for Potential Nose-to-Brain Targeting of Idebenone

Idebenone (IDE) is a powerful antioxidant that is potentially active towards cerebral diseases, but its low water solubility and fast first pass metabolism reduce its accumulation in the brain, making it ineffective. In this work, we developed cyclodextrin-based chitosan nanospheres (CS NPs) as pote...

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Detalles Bibliográficos
Autores principales: De Gaetano, Federica, d’Avanzo, Nicola, Mancuso, Antonia, De Gaetano, Anna, Paladini, Giuseppe, Caridi, Francesco, Venuti, Valentina, Paolino, Donatella, Ventura, Cinzia Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612377/
https://www.ncbi.nlm.nih.gov/pubmed/36297318
http://dx.doi.org/10.3390/ph15101206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612377/
https://www.ncbi.nlm.nih.gov/pubmed/36297318
http://dx.doi.org/10.3390/ph15101206

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