Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects

Acid-sensing ion channels (ASICs) are voltage-independent H(+)-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b, 3 and 4) associate into homotrimers or heterotrimers to form functional channels with highly pH-dependent gat...

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Detalles Bibliográficos
Autores principales: Verkest, Clément, Salinas, Miguel, Diochot, Sylvie, Deval, Emmanuel, Lingueglia, Eric, Baron, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612379/
https://www.ncbi.nlm.nih.gov/pubmed/36287977
http://dx.doi.org/10.3390/toxins14100709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612379/
https://www.ncbi.nlm.nih.gov/pubmed/36287977
http://dx.doi.org/10.3390/toxins14100709

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