Microglia have limited influence on early prion pathogenesis, clearance, or replication

Microglia (MG) are critical to host defense during prion infection, but the mechanism(s) of this neuroprotection are poorly understood. To better examine the influence of MG during prion infection, we reduced MG in the brains of C57BL/10 mice using PLX5622 and assessed prion clearance and replicatio...

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Detalles Bibliográficos
Autores principales: Race, Brent, Williams, Katie, Baune, Chase, Striebel, James F., Long, Dan, Thomas, Tina, Lubke, Lori, Chesebro, Bruce, Carroll, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612458/
https://www.ncbi.nlm.nih.gov/pubmed/36301895
http://dx.doi.org/10.1371/journal.pone.0276850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612458/
https://www.ncbi.nlm.nih.gov/pubmed/36301895
http://dx.doi.org/10.1371/journal.pone.0276850

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