The lymphocyte-specific protein tyrosine kinase-specific inhibitor A-770041 attenuates lung fibrosis via the suppression of TGF-β production in regulatory T-cells

BACKGROUND: Lymphocyte-specific protein tyrosine kinase (Lck) is a member of the Src family of tyrosine kinases. The significance of Lck inhibition in lung fibrosis has not yet been fully elucidated, even though lung fibrosis is commonly preceded by inflammation caused by infiltration of T-cells exp...

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Detalles Bibliográficos
Autores principales: Kagawa, Kozo, Sato, Seidai, Koyama, Kazuya, Imakura, Takeshi, Murakami, Kojin, Yamashita, Yuya, Naito, Nobuhito, Ogawa, Hirohisa, Kawano, Hiroshi, Nishioka, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612470/
https://www.ncbi.nlm.nih.gov/pubmed/36301948
http://dx.doi.org/10.1371/journal.pone.0275987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612470/
https://www.ncbi.nlm.nih.gov/pubmed/36301948
http://dx.doi.org/10.1371/journal.pone.0275987

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