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Stability and expression of SARS-CoV-2 spike-protein mutations

Protein fold stability likely plays a role in SARS-CoV-2 S-protein evolution, together with ACE2 binding and antibody evasion. While few thermodynamic stability data are available for S-protein mutants, many systematic experimental data exist for their expression. In this paper, we explore whether s...

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Detalles Bibliográficos
Autores principales: Bæk, Kristoffer T., Mehra, Rukmankesh, Kepp, Kasper P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612610/
https://www.ncbi.nlm.nih.gov/pubmed/36302994
http://dx.doi.org/10.1007/s11010-022-04588-w