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Kinetic and data-driven modeling of pancreatic β-cell central carbon metabolism and insulin secretion

Pancreatic β-cells respond to increased extracellular glucose levels by initiating a metabolic shift. That change in metabolism is part of the process of glucose-stimulated insulin secretion and is of particular interest in the context of diabetes. However, we do not fully understand how the coordin...

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Detalles Bibliográficos
Autores principales: Gelbach, Patrick E., Zheng, Dongqing, Fraser, Scott E., White, Kate L., Graham, Nicholas A., Finley, Stacey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612825/
https://www.ncbi.nlm.nih.gov/pubmed/36251711
http://dx.doi.org/10.1371/journal.pcbi.1010555