DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells

Myeloid malignancies with DDX41 mutations are often associated with bone marrow failure and cytopenia before overt disease manifestation. However, the mechanisms underlying these specific conditions remain elusive. Here, we demonstrate that loss of DDX41 function impairs efficient RNA splicing, resu...

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Detalles Bibliográficos
Autores principales: Shinriki, Satoru, Hirayama, Mayumi, Nagamachi, Akiko, Yokoyama, Akihiko, Kawamura, Takeshi, Kanai, Akinori, Kawai, Hidehiko, Iwakiri, Junichi, Liu, Rin, Maeshiro, Manabu, Tungalag, Saruul, Tasaki, Masayoshi, Ueda, Mitsuharu, Tomizawa, Kazuhito, Kataoka, Naoyuki, Ideue, Takashi, Suzuki, Yutaka, Asai, Kiyoshi, Tani, Tokio, Inaba, Toshiya, Matsui, Hirotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613458/
https://www.ncbi.nlm.nih.gov/pubmed/36229594
http://dx.doi.org/10.1038/s41375-022-01708-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613458/
https://www.ncbi.nlm.nih.gov/pubmed/36229594
http://dx.doi.org/10.1038/s41375-022-01708-9

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