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Dentoalveolar Defects of Hypophosphatasia are Recapitulated in a Sheep Knock‐In Model

Hypophosphatasia (HPP) is the inherited error‐of‐metabolism caused by mutations in ALPL, reducing the function of tissue‐nonspecific alkaline phosphatase (TNAP/TNALP/TNSALP). HPP is characterized by defective skeletal and dental mineralization and is categorized into several clinical subtypes based...

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Detalles Bibliográficos
Autores principales: Mohamed, Fatma F., Chavez, Michael B., Huggins, Shannon, Bertels, Joshua, Falck, Alyssa, Suva, Larry J., Foster, Brian L., Gaddy, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613530/
https://www.ncbi.nlm.nih.gov/pubmed/36053890
http://dx.doi.org/10.1002/jbmr.4666