Targeting vasoactive intestinal peptide-mediated signaling enhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma

A paucity of effector T cells within tumors renders pancreatic ductal adenocarcinoma (PDAC) resistant to immune checkpoint therapies. While several under-development approaches target immune-suppressive cells in the tumor microenvironment, there is less focus on improving T cell function. Here we sh...

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Detalles Bibliográficos
Autores principales: Ravindranathan, Sruthi, Passang, Tenzin, Li, Jian-Ming, Wang, Shuhua, Dhamsania, Rohan, Ware, Michael Brandon, Zaidi, Mohammad Y., Zhu, Jingru, Cardenas, Maria, Liu, Yuan, Gumber, Sanjeev, Robinson, Brian, Sen-Majumdar, Anish, Zhang, Hanwen, Chandrakasan, Shanmuganathan, Kissick, Haydn, Frey, Alan B., Thomas, Susan N., El-Rayes, Bassel F., Lesinski, Gregory B., Waller, Edmund K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613684/
https://www.ncbi.nlm.nih.gov/pubmed/36302761
http://dx.doi.org/10.1038/s41467-022-34242-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613684/
https://www.ncbi.nlm.nih.gov/pubmed/36302761
http://dx.doi.org/10.1038/s41467-022-34242-4

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