A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation

Translational stalling events that result in ribosome collisions induce Ribosome-associated Quality Control (RQC) in order to degrade potentially toxic truncated nascent proteins. For RQC induction, the collided ribosomes are first marked by the Hel2/ZNF598 E3 ubiquitin ligase to recruit the RQT com...

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Detalles Bibliográficos
Autores principales: Narita, Momoko, Denk, Timo, Matsuo, Yoshitaka, Sugiyama, Takato, Kikuguchi, Chisato, Ito, Sota, Sato, Nichika, Suzuki, Toru, Hashimoto, Satoshi, Machová, Iva, Tesina, Petr, Beckmann, Roland, Inada, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613687/
https://www.ncbi.nlm.nih.gov/pubmed/36302773
http://dx.doi.org/10.1038/s41467-022-34097-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613687/
https://www.ncbi.nlm.nih.gov/pubmed/36302773
http://dx.doi.org/10.1038/s41467-022-34097-9

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