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A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation
Translational stalling events that result in ribosome collisions induce Ribosome-associated Quality Control (RQC) in order to degrade potentially toxic truncated nascent proteins. For RQC induction, the collided ribosomes are first marked by the Hel2/ZNF598 E3 ubiquitin ligase to recruit the RQT com...
Autores principales: | Narita, Momoko, Denk, Timo, Matsuo, Yoshitaka, Sugiyama, Takato, Kikuguchi, Chisato, Ito, Sota, Sato, Nichika, Suzuki, Toru, Hashimoto, Satoshi, Machová, Iva, Tesina, Petr, Beckmann, Roland, Inada, Toshifumi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613687/ https://www.ncbi.nlm.nih.gov/pubmed/36302773 http://dx.doi.org/10.1038/s41467-022-34097-9 |
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