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Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control
Translation termination requires release factors that read a STOP codon in the decoding center and subsequently facilitate the hydrolysis of the nascent peptide chain from the peptidyl tRNA within the ribosome. In human mitochondria eleven open reading frames terminate in the standard UAA or UAG STO...
Autores principales: | Nadler, Franziska, Lavdovskaia, Elena, Krempler, Angelique, Cruz-Zaragoza, Luis Daniel, Dennerlein, Sven, Richter-Dennerlein, Ricarda |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613700/ https://www.ncbi.nlm.nih.gov/pubmed/36302763 http://dx.doi.org/10.1038/s41467-022-34088-w |
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