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Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states
Intrinsically disordered proteins, which do not adopt well-defined structures under physiological conditions, are implicated in many human diseases. Small molecules that target the disordered transactivation domain of the androgen receptor have entered human trials for the treatment of castration-re...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613762/ https://www.ncbi.nlm.nih.gov/pubmed/36302916 http://dx.doi.org/10.1038/s41467-022-34077-z |