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Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states

Intrinsically disordered proteins, which do not adopt well-defined structures under physiological conditions, are implicated in many human diseases. Small molecules that target the disordered transactivation domain of the androgen receptor have entered human trials for the treatment of castration-re...

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Detalles Bibliográficos
Autores principales:	Zhu, Jiaqi, Salvatella, Xavier, Robustelli, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613762/ https://www.ncbi.nlm.nih.gov/pubmed/36302916 http://dx.doi.org/10.1038/s41467-022-34077-z

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