Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells

Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine for anabolic growth and survival. Herein, we investigated the cell death mechanism activated in glutamine-addicted tumor cells in response to the limitation of glutamine metabo...

Descripción completa

Detalles Bibliográficos
Autores principales: Yerbes, Rosario, Mora-Molina, Rocío, Fernández-Farrán, F. Javier, Hiraldo, Laura, López-Rivas, Abelardo, Palacios, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613879/
https://www.ncbi.nlm.nih.gov/pubmed/36302756
http://dx.doi.org/10.1038/s41419-022-05346-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613879/
https://www.ncbi.nlm.nih.gov/pubmed/36302756
http://dx.doi.org/10.1038/s41419-022-05346-y

Ejemplares similares