ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fibrosis and dysfunction via regulating ACE2 shedding and myofibroblast transformation

A disintegrin and metalloprotease domain family protein 17 (ADAM17) is a new member of renin-angiotensin system (RAS) but its role in the pathogenesis of diabetic cardiomyopathy (DCM) is obscure. To test the hypothesis that ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fi...

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Detalles Bibliográficos
Autores principales: Cheng, Jing, Xue, Fei, Cheng, Cheng, Sui, Wenhai, Zhang, Meng, Qiao, Lei, Ma, Jing, Ji, Xiaoping, Chen, Wenqiang, Yu, Xiao, Xi, Bo, Xu, Feng, Su, Guohai, Zhao, Yuxia, Hao, Panpan, Zhang, Yun, Zhang, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613967/
https://www.ncbi.nlm.nih.gov/pubmed/36313337
http://dx.doi.org/10.3389/fphar.2022.997916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613967/
https://www.ncbi.nlm.nih.gov/pubmed/36313337
http://dx.doi.org/10.3389/fphar.2022.997916

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