In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys

PURPOSE: Sotrovimab (VIR-7831), a human IgG1κ monoclonal antibody (mAb), binds to a conserved epitope on the SARS-CoV-2 spike protein receptor binding domain (RBD). The Fc region of VIR-7831 contains an LS modification to promote neonatal Fc receptor (FcRn)–mediated recycling and extend its serum ha...

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Detalles Bibliográficos
Autores principales: Aweda, Tolulope A., Cheng, Shih-Hsun, Lenhard, Stephen C., Sepp, Armin, Skedzielewski, Tinamarie, Hsu, Chih-Yang, Marshall, Shelly, Haag, Heather, Kehler, Jonathan, Jagdale, Prabhas, Peter, Alessia, Schmid, Michael A., Gehman, Andrew, Doan, Minh, Mayer, Andrew P., Gorycki, Peter, Fanget, Marie, Colas, Christophe, Smith, Brenda, Maier, Curtis C., Alsaid, Hasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614201/
https://www.ncbi.nlm.nih.gov/pubmed/36305907
http://dx.doi.org/10.1007/s00259-022-06012-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614201/
https://www.ncbi.nlm.nih.gov/pubmed/36305907
http://dx.doi.org/10.1007/s00259-022-06012-3

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