Cargando…

Dietary Forsythia suspensa extracts supplementation improves antioxidant status, anti-inflammatory functions, meat fatty acid deposition, and intestinal microbial community in finishing pigs

This study aimed to determine the effects of Forsythia suspensa extracts (FSE) on performance, antioxidant status, inflammatory cytokines, meat quality, meat fatty acid composition, and gut microbial community in finishing pigs. Sixty-four pigs [Duroc × (Landrace × Yorkshire)] with an average initia...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Sujie, Wang, Qianqian, Ma, Jiayu, Wang, Jian, Wang, Hongliang, Liu, Li, Long, Shenfei, Piao, Xiangshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614228/
https://www.ncbi.nlm.nih.gov/pubmed/36311660
http://dx.doi.org/10.3389/fvets.2022.960242
_version_ 1784820150378168320
author Liu, Sujie
Wang, Qianqian
Ma, Jiayu
Wang, Jian
Wang, Hongliang
Liu, Li
Long, Shenfei
Piao, Xiangshu
author_facet Liu, Sujie
Wang, Qianqian
Ma, Jiayu
Wang, Jian
Wang, Hongliang
Liu, Li
Long, Shenfei
Piao, Xiangshu
author_sort Liu, Sujie
collection PubMed
description This study aimed to determine the effects of Forsythia suspensa extracts (FSE) on performance, antioxidant status, inflammatory cytokines, meat quality, meat fatty acid composition, and gut microbial community in finishing pigs. Sixty-four pigs [Duroc × (Landrace × Yorkshire)] with an average initial body weight of 88.68 kg were randomly allotted to two dietary treatments, with eight replicate pens per treatment (four pens were barrows and four pens were gilts), four pigs per pen. The dietary treatments included a corn–soybean meal basal diet (CON) and an FS diet (basal diet + 100 mg/kg FSE; FS). Compared with CON, pigs fed FSE showed enhanced (P < 0.05) saturated fatty acid (SFA)/polyunsaturated fatty acid (PUFA) ratio, reduced (P < 0.05) lightness, and n−6/n−3 PUFA ratio, as well as tended to increase C20:5n3 content in the longissimus dorsi muscle. Moreover, pigs fed FSE showed decreased (P < 0.05) serum cortisol and tumor nuclear factor-α contents, and increased (P < 0.05) serum high-density lipoprotein cholesterol, superoxide dismutase, and glutathione peroxidase contents compared with CON. These pigs also tended to have increased serum total protein and immunoglobulin G contents, and decreased serum low-density lipoprotein cholesterol and interleukin-1β contents compared with CON. In the colon, pigs fed FSE had a higher (P < 0.05) relative abundance of Bifidobacteriales at the order level, Lactobacillaceae and Bifidobacteriaceae at the family level, as well as Lactobacillus and Bifidobacterium at the genus level compared with CON. In conclusion, dietary Forsythia suspensa extract supplementation effectively improved antioxidant status and anti-inflammatory functions, as well as modulated meat fatty acid composition, and gut microbial community in finishing pigs.
format Online
Article
Text
id pubmed-9614228
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96142282022-10-29 Dietary Forsythia suspensa extracts supplementation improves antioxidant status, anti-inflammatory functions, meat fatty acid deposition, and intestinal microbial community in finishing pigs Liu, Sujie Wang, Qianqian Ma, Jiayu Wang, Jian Wang, Hongliang Liu, Li Long, Shenfei Piao, Xiangshu Front Vet Sci Veterinary Science This study aimed to determine the effects of Forsythia suspensa extracts (FSE) on performance, antioxidant status, inflammatory cytokines, meat quality, meat fatty acid composition, and gut microbial community in finishing pigs. Sixty-four pigs [Duroc × (Landrace × Yorkshire)] with an average initial body weight of 88.68 kg were randomly allotted to two dietary treatments, with eight replicate pens per treatment (four pens were barrows and four pens were gilts), four pigs per pen. The dietary treatments included a corn–soybean meal basal diet (CON) and an FS diet (basal diet + 100 mg/kg FSE; FS). Compared with CON, pigs fed FSE showed enhanced (P < 0.05) saturated fatty acid (SFA)/polyunsaturated fatty acid (PUFA) ratio, reduced (P < 0.05) lightness, and n−6/n−3 PUFA ratio, as well as tended to increase C20:5n3 content in the longissimus dorsi muscle. Moreover, pigs fed FSE showed decreased (P < 0.05) serum cortisol and tumor nuclear factor-α contents, and increased (P < 0.05) serum high-density lipoprotein cholesterol, superoxide dismutase, and glutathione peroxidase contents compared with CON. These pigs also tended to have increased serum total protein and immunoglobulin G contents, and decreased serum low-density lipoprotein cholesterol and interleukin-1β contents compared with CON. In the colon, pigs fed FSE had a higher (P < 0.05) relative abundance of Bifidobacteriales at the order level, Lactobacillaceae and Bifidobacteriaceae at the family level, as well as Lactobacillus and Bifidobacterium at the genus level compared with CON. In conclusion, dietary Forsythia suspensa extract supplementation effectively improved antioxidant status and anti-inflammatory functions, as well as modulated meat fatty acid composition, and gut microbial community in finishing pigs. Frontiers Media S.A. 2022-10-14 /pmc/articles/PMC9614228/ /pubmed/36311660 http://dx.doi.org/10.3389/fvets.2022.960242 Text en Copyright © 2022 Liu, Wang, Ma, Wang, Wang, Liu, Long and Piao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Liu, Sujie
Wang, Qianqian
Ma, Jiayu
Wang, Jian
Wang, Hongliang
Liu, Li
Long, Shenfei
Piao, Xiangshu
Dietary Forsythia suspensa extracts supplementation improves antioxidant status, anti-inflammatory functions, meat fatty acid deposition, and intestinal microbial community in finishing pigs
title Dietary Forsythia suspensa extracts supplementation improves antioxidant status, anti-inflammatory functions, meat fatty acid deposition, and intestinal microbial community in finishing pigs
title_full Dietary Forsythia suspensa extracts supplementation improves antioxidant status, anti-inflammatory functions, meat fatty acid deposition, and intestinal microbial community in finishing pigs
title_fullStr Dietary Forsythia suspensa extracts supplementation improves antioxidant status, anti-inflammatory functions, meat fatty acid deposition, and intestinal microbial community in finishing pigs
title_full_unstemmed Dietary Forsythia suspensa extracts supplementation improves antioxidant status, anti-inflammatory functions, meat fatty acid deposition, and intestinal microbial community in finishing pigs
title_short Dietary Forsythia suspensa extracts supplementation improves antioxidant status, anti-inflammatory functions, meat fatty acid deposition, and intestinal microbial community in finishing pigs
title_sort dietary forsythia suspensa extracts supplementation improves antioxidant status, anti-inflammatory functions, meat fatty acid deposition, and intestinal microbial community in finishing pigs
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614228/
https://www.ncbi.nlm.nih.gov/pubmed/36311660
http://dx.doi.org/10.3389/fvets.2022.960242
work_keys_str_mv AT liusujie dietaryforsythiasuspensaextractssupplementationimprovesantioxidantstatusantiinflammatoryfunctionsmeatfattyaciddepositionandintestinalmicrobialcommunityinfinishingpigs
AT wangqianqian dietaryforsythiasuspensaextractssupplementationimprovesantioxidantstatusantiinflammatoryfunctionsmeatfattyaciddepositionandintestinalmicrobialcommunityinfinishingpigs
AT majiayu dietaryforsythiasuspensaextractssupplementationimprovesantioxidantstatusantiinflammatoryfunctionsmeatfattyaciddepositionandintestinalmicrobialcommunityinfinishingpigs
AT wangjian dietaryforsythiasuspensaextractssupplementationimprovesantioxidantstatusantiinflammatoryfunctionsmeatfattyaciddepositionandintestinalmicrobialcommunityinfinishingpigs
AT wanghongliang dietaryforsythiasuspensaextractssupplementationimprovesantioxidantstatusantiinflammatoryfunctionsmeatfattyaciddepositionandintestinalmicrobialcommunityinfinishingpigs
AT liuli dietaryforsythiasuspensaextractssupplementationimprovesantioxidantstatusantiinflammatoryfunctionsmeatfattyaciddepositionandintestinalmicrobialcommunityinfinishingpigs
AT longshenfei dietaryforsythiasuspensaextractssupplementationimprovesantioxidantstatusantiinflammatoryfunctionsmeatfattyaciddepositionandintestinalmicrobialcommunityinfinishingpigs
AT piaoxiangshu dietaryforsythiasuspensaextractssupplementationimprovesantioxidantstatusantiinflammatoryfunctionsmeatfattyaciddepositionandintestinalmicrobialcommunityinfinishingpigs