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Influence of traditional processing and genotypes on the antioxidant and antihyperglycaemic activities of yellow-fleshed cassava

Yellow-fleshed cassava root (YFCR) is processed into traditional products that may influence its bioactivities. In this study, the antioxidant and anti-hyperglycaemic activities of three traditional products (lafun, fufu and gari) from five genotypes (IITA-TMS-IBA070337, 182961, 182962, 182986, 1830...

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Autores principales: Kareem, Babajide, Irondi, Emmanuel Anyachukwu, Alamu, Emmanuel Oladeji, Ajani, Emmanuel Oladipo, Abass, Adebayo, Adesokan, Michael, Parkes, Elizabeth, Maziya-Dixon, Busie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614258/
https://www.ncbi.nlm.nih.gov/pubmed/36313071
http://dx.doi.org/10.3389/fnut.2022.894843
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author Kareem, Babajide
Irondi, Emmanuel Anyachukwu
Alamu, Emmanuel Oladeji
Ajani, Emmanuel Oladipo
Abass, Adebayo
Adesokan, Michael
Parkes, Elizabeth
Maziya-Dixon, Busie
author_facet Kareem, Babajide
Irondi, Emmanuel Anyachukwu
Alamu, Emmanuel Oladeji
Ajani, Emmanuel Oladipo
Abass, Adebayo
Adesokan, Michael
Parkes, Elizabeth
Maziya-Dixon, Busie
author_sort Kareem, Babajide
collection PubMed
description Yellow-fleshed cassava root (YFCR) is processed into traditional products that may influence its bioactivities. In this study, the antioxidant and anti-hyperglycaemic activities of three traditional products (lafun, fufu and gari) from five genotypes (IITA-TMS-IBA070337, 182961, 182962, 182986, 183044) of YFCR were evaluated. The YFCR genotypes were grown at the International Institute of Tropical Agriculture (IITA) research field, Ibadan. The bioactive constituents (total carotenoids, total phenolics, tannins and total flavonoids), antioxidant [2,2-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) radical cation (ABTS(•+)) and 1,1-diphenyl-2- picrylhydrazyl radical (DPPH(•)) scavenging capacities, and reducing power], and starch-digesting enzymes (α-amylase and α-glucosidase) inhibitory activities of the products were determined using standard laboratory methods. The glucose response of the products was assessed in human subjects. The concentrations of the bioactive constituents of the products from different genotypes varied significantly (p < 0.05). The ABTS(•+) and DPPH(•) scavenging capacities and the reducing power of the products also differed significantly (p < 0.05), such that the lafun from IITA-TMS-IBA182962, IITA-TMS-IBA070337 and IITA-TMS-IBA070337 had the strongest ABTS(•+) and DPPH(•) scavenging capacities, and reducing power, respectively. The α-amylase and α-glucosidase inhibitory activities of the three products differed significantly (p < 0.05), with the lafun from IITA-TMS-IBA070337 and IITA-TMS-IBA07033 having the strongest α-amylase and α-glucosidase inhibitory activity, respectively. Also, the lafun from IITA-TMS-182986 had the least glucose response, while the fufu from IITA-TMS-IBA070337 had the highest glucose response. Overall, the lafun from different genotypes of YFCR had the most potent antioxidant and starch-digesting enzymes inhibitory activities and the least glucose responses. Hence, lafun may be a promising dietary intervention targeting oxidative stress, hyperglycaemia, and their resultant type 2 diabetes.
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spelling pubmed-96142582022-10-29 Influence of traditional processing and genotypes on the antioxidant and antihyperglycaemic activities of yellow-fleshed cassava Kareem, Babajide Irondi, Emmanuel Anyachukwu Alamu, Emmanuel Oladeji Ajani, Emmanuel Oladipo Abass, Adebayo Adesokan, Michael Parkes, Elizabeth Maziya-Dixon, Busie Front Nutr Nutrition Yellow-fleshed cassava root (YFCR) is processed into traditional products that may influence its bioactivities. In this study, the antioxidant and anti-hyperglycaemic activities of three traditional products (lafun, fufu and gari) from five genotypes (IITA-TMS-IBA070337, 182961, 182962, 182986, 183044) of YFCR were evaluated. The YFCR genotypes were grown at the International Institute of Tropical Agriculture (IITA) research field, Ibadan. The bioactive constituents (total carotenoids, total phenolics, tannins and total flavonoids), antioxidant [2,2-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) radical cation (ABTS(•+)) and 1,1-diphenyl-2- picrylhydrazyl radical (DPPH(•)) scavenging capacities, and reducing power], and starch-digesting enzymes (α-amylase and α-glucosidase) inhibitory activities of the products were determined using standard laboratory methods. The glucose response of the products was assessed in human subjects. The concentrations of the bioactive constituents of the products from different genotypes varied significantly (p < 0.05). The ABTS(•+) and DPPH(•) scavenging capacities and the reducing power of the products also differed significantly (p < 0.05), such that the lafun from IITA-TMS-IBA182962, IITA-TMS-IBA070337 and IITA-TMS-IBA070337 had the strongest ABTS(•+) and DPPH(•) scavenging capacities, and reducing power, respectively. The α-amylase and α-glucosidase inhibitory activities of the three products differed significantly (p < 0.05), with the lafun from IITA-TMS-IBA070337 and IITA-TMS-IBA07033 having the strongest α-amylase and α-glucosidase inhibitory activity, respectively. Also, the lafun from IITA-TMS-182986 had the least glucose response, while the fufu from IITA-TMS-IBA070337 had the highest glucose response. Overall, the lafun from different genotypes of YFCR had the most potent antioxidant and starch-digesting enzymes inhibitory activities and the least glucose responses. Hence, lafun may be a promising dietary intervention targeting oxidative stress, hyperglycaemia, and their resultant type 2 diabetes. Frontiers Media S.A. 2022-10-14 /pmc/articles/PMC9614258/ /pubmed/36313071 http://dx.doi.org/10.3389/fnut.2022.894843 Text en Copyright © 2022 Kareem, Irondi, Alamu, Ajani, Abass, Adesokan, Parkes and Maziya-Dixon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Kareem, Babajide
Irondi, Emmanuel Anyachukwu
Alamu, Emmanuel Oladeji
Ajani, Emmanuel Oladipo
Abass, Adebayo
Adesokan, Michael
Parkes, Elizabeth
Maziya-Dixon, Busie
Influence of traditional processing and genotypes on the antioxidant and antihyperglycaemic activities of yellow-fleshed cassava
title Influence of traditional processing and genotypes on the antioxidant and antihyperglycaemic activities of yellow-fleshed cassava
title_full Influence of traditional processing and genotypes on the antioxidant and antihyperglycaemic activities of yellow-fleshed cassava
title_fullStr Influence of traditional processing and genotypes on the antioxidant and antihyperglycaemic activities of yellow-fleshed cassava
title_full_unstemmed Influence of traditional processing and genotypes on the antioxidant and antihyperglycaemic activities of yellow-fleshed cassava
title_short Influence of traditional processing and genotypes on the antioxidant and antihyperglycaemic activities of yellow-fleshed cassava
title_sort influence of traditional processing and genotypes on the antioxidant and antihyperglycaemic activities of yellow-fleshed cassava
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614258/
https://www.ncbi.nlm.nih.gov/pubmed/36313071
http://dx.doi.org/10.3389/fnut.2022.894843
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