Allogeneic and xenogeneic lymphoid reconstitution in a RAG2(−/−)IL2RG(y/−) severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation

Mice with severe combined immunodeficiency are commonly used as hosts of human cells. Size, longevity, and physiology, however, limit the extent to which immunodeficient mice can model human systems. To address these limitations, we generated RAG2(−/−) IL2RG(y/−) immunodeficient pigs and demonstrate...

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Detalles Bibliográficos
Autores principales: Sper, Renan B., Proctor, Jessica, Lascina, Odessa, Guo, Ling, Polkoff, Kathryn, Kaeser, Tobias, Simpson, Sean, Borst, Luke, Gleason, Katherine, Zhang, Xia, Collins, Bruce, Murphy, Yanet, Platt, Jeffrey L., Piedrahita, Jorge A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614384/
https://www.ncbi.nlm.nih.gov/pubmed/36311661
http://dx.doi.org/10.3389/fvets.2022.965316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614384/
https://www.ncbi.nlm.nih.gov/pubmed/36311661
http://dx.doi.org/10.3389/fvets.2022.965316

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