Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia

Pre-leukemic clones carrying DNMT3A mutations have a selective advantage and an inherent chemoresistance, however the basis for this phenotype has not been fully elucidated. Mutations affecting the gene TP53 occur in pre-leukemic hema-topoietic stem/progenitor cells (preL-HSPC) and lead to chemoresi...

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Detalles Bibliográficos
Autores principales: Tuval, Amos, Brilon, Yardena, Azogy, Hadas, Moskovitz, Yoni, Leshkowitz, Dena, Salame, Tomer M, Minden, Mark D, Tal, Perry, Rotter, Varda, Oren, Moshe, Kaushansky, Nathali, Shlush, Liran I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Acute Myeloid Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614533/
https://www.ncbi.nlm.nih.gov/pubmed/35199506
http://dx.doi.org/10.3324/haematol.2021.280329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614533/
https://www.ncbi.nlm.nih.gov/pubmed/35199506
http://dx.doi.org/10.3324/haematol.2021.280329

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