Synthesis of novel chiral spiro-β-lactams from nitrile oxides and 6-(Z)-(benzoylmethylene)penicillanate: batch, microwave-induced and continuous flow methodologies

The first examples of the diastereoselective 1,3-dipolar cycloaddition reaction of nitrile oxides and 6-alkylidene penicillanates leading to chiral spiroisoxazoline-penicillanates are reported. The synthesis of this new type of penicillanate involved the selective generation of two consecutive stere...

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Detalles Bibliográficos
Autores principales: Alves, Américo J. S., Silvestre, João A. D., Pinho e Melo, Teresa M. V. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614636/
https://www.ncbi.nlm.nih.gov/pubmed/36349033
http://dx.doi.org/10.1039/d2ra04848e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614636/
https://www.ncbi.nlm.nih.gov/pubmed/36349033
http://dx.doi.org/10.1039/d2ra04848e

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