Cytidine-containing tails robustly enhance and prolong protein production of synthetic mRNA in cell and in vivo

Synthetic mRNAs are rising rapidly as alternative therapeutic agents for delivery of proteins. However, the practical use of synthetic mRNAs has been restricted by their low cellular stability as well as poor protein production efficiency. The key roles of poly(A) tail on mRNA biology inspire us to...

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Detalles Bibliográficos
Autores principales: Li, Cheuk Yin, Liang, Zhenghua, Hu, Yaxin, Zhang, Hongxia, Setiasabda, Kharis Daniel, Li, Jiawei, Ma, Shaohua, Xia, Xiaojun, Kuang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614650/
https://www.ncbi.nlm.nih.gov/pubmed/36320322
http://dx.doi.org/10.1016/j.omtn.2022.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614650/
https://www.ncbi.nlm.nih.gov/pubmed/36320322
http://dx.doi.org/10.1016/j.omtn.2022.10.003

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