ER Redox Homeostasis Regulates Proinsulin Trafficking and Insulin Granule Formation in the Pancreatic Islet β-Cell

Defects in the pancreatic β-cell’s secretion system are well-described in type 2 diabetes (T2D) and include impaired proinsulin processing and a deficit in mature insulin-containing secretory granules; however, the cellular mechanisms underlying these defects remain poorly understood. To address thi...

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Detalles Bibliográficos
Autores principales: Rohli, Kristen E, Boyer, Cierra K, Bearrows, Shelby C, Moyer, Marshall R, Elison, Weston S, Bauchle, Casey J, Blom, Sandra E, Zhang, Jianchao, Wang, Yanzhuang, Stephens, Samuel B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614934/
https://www.ncbi.nlm.nih.gov/pubmed/36325514
http://dx.doi.org/10.1093/function/zqac051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614934/
https://www.ncbi.nlm.nih.gov/pubmed/36325514
http://dx.doi.org/10.1093/function/zqac051

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