Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform

[Image: see text] Small-molecule drug target identification is an essential and often rate-limiting step in phenotypic drug discovery and remains a major challenge. Here, we report a novel platform for target identification of activators of signaling pathways by leveraging the power of a clustered r...

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Detalles Bibliográficos
Autores principales: Zhao, Junxing, Tang, Zhichao, Selvaraju, Manikandan, Johnson, Kristen A., Douglas, Justin T., Gao, Philip F., Petrassi, H. Michael, Wang, Michael Zhuo, Wang, Jingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615120/
https://www.ncbi.nlm.nih.gov/pubmed/36313155
http://dx.doi.org/10.1021/acscentsci.2c00609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615120/
https://www.ncbi.nlm.nih.gov/pubmed/36313155
http://dx.doi.org/10.1021/acscentsci.2c00609

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