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Translational alterations in pancreatic cancer: a central role for the integrated stress response
mRNA translation is a key mechanism for cancer cell proliferation and stress adaptation. Regulation of this machinery implicates upstream pathways such as PI3K/AKT/mTOR, RAS/MEK/ERK and the integrated stress response (ISR), principally coordinating the translation initiation step. During the last de...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615149/ https://www.ncbi.nlm.nih.gov/pubmed/36325577 http://dx.doi.org/10.1093/narcan/zcac031 |
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author | Shin, Sauyeun Solorzano, Jacobo Liauzun, Mehdi Pyronnet, Stéphane Bousquet, Corinne Martineau, Yvan |
author_facet | Shin, Sauyeun Solorzano, Jacobo Liauzun, Mehdi Pyronnet, Stéphane Bousquet, Corinne Martineau, Yvan |
author_sort | Shin, Sauyeun |
collection | PubMed |
description | mRNA translation is a key mechanism for cancer cell proliferation and stress adaptation. Regulation of this machinery implicates upstream pathways such as PI3K/AKT/mTOR, RAS/MEK/ERK and the integrated stress response (ISR), principally coordinating the translation initiation step. During the last decade, dysregulation of the mRNA translation process in pancreatic cancer has been widely reported, and shown to critically impact on cancer initiation, development and survival. This includes translation dysregulation of mRNAs encoding oncogenes and tumor suppressors. Hence, cancer cells survive a stressful microenvironment through a flexible regulation of translation initiation for rapid adaptation. The ISR pathway has an important role in chemoresistance and shows high potential therapeutic interest. Despite the numerous translational alterations reported in pancreatic cancer, their consequences are greatly underestimated. In this review, we summarize the different translation dysregulations described in pancreatic cancer, which make it invulnerable, as well as the latest drug discoveries bringing a glimmer of hope. |
format | Online Article Text |
id | pubmed-9615149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-96151492022-11-01 Translational alterations in pancreatic cancer: a central role for the integrated stress response Shin, Sauyeun Solorzano, Jacobo Liauzun, Mehdi Pyronnet, Stéphane Bousquet, Corinne Martineau, Yvan NAR Cancer Critical Reviews and Perspectives mRNA translation is a key mechanism for cancer cell proliferation and stress adaptation. Regulation of this machinery implicates upstream pathways such as PI3K/AKT/mTOR, RAS/MEK/ERK and the integrated stress response (ISR), principally coordinating the translation initiation step. During the last decade, dysregulation of the mRNA translation process in pancreatic cancer has been widely reported, and shown to critically impact on cancer initiation, development and survival. This includes translation dysregulation of mRNAs encoding oncogenes and tumor suppressors. Hence, cancer cells survive a stressful microenvironment through a flexible regulation of translation initiation for rapid adaptation. The ISR pathway has an important role in chemoresistance and shows high potential therapeutic interest. Despite the numerous translational alterations reported in pancreatic cancer, their consequences are greatly underestimated. In this review, we summarize the different translation dysregulations described in pancreatic cancer, which make it invulnerable, as well as the latest drug discoveries bringing a glimmer of hope. Oxford University Press 2022-10-28 /pmc/articles/PMC9615149/ /pubmed/36325577 http://dx.doi.org/10.1093/narcan/zcac031 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of NAR Cancer. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Critical Reviews and Perspectives Shin, Sauyeun Solorzano, Jacobo Liauzun, Mehdi Pyronnet, Stéphane Bousquet, Corinne Martineau, Yvan Translational alterations in pancreatic cancer: a central role for the integrated stress response |
title | Translational alterations in pancreatic cancer: a central role for the integrated stress response |
title_full | Translational alterations in pancreatic cancer: a central role for the integrated stress response |
title_fullStr | Translational alterations in pancreatic cancer: a central role for the integrated stress response |
title_full_unstemmed | Translational alterations in pancreatic cancer: a central role for the integrated stress response |
title_short | Translational alterations in pancreatic cancer: a central role for the integrated stress response |
title_sort | translational alterations in pancreatic cancer: a central role for the integrated stress response |
topic | Critical Reviews and Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615149/ https://www.ncbi.nlm.nih.gov/pubmed/36325577 http://dx.doi.org/10.1093/narcan/zcac031 |
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