HIV Tat and cocaine interactively alter genome-wide DNA methylation and gene expression and exacerbate learning and memory impairments

Cocaine use is a major comorbidity of HIV-associated neurocognitive disorder (HAND). In this study, we show that cocaine exposure worsens the learning and memory of doxycycline-inducible and brain-specific HIV Tat transgenic mice (iTat) and results in 14,838 hypermethylated CpG-related differentiall...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Xiaojie, Zhang, Fan, Kandel, Suresh R., Brau, Frédéric, He, Johnny J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615417/
https://www.ncbi.nlm.nih.gov/pubmed/35508123
http://dx.doi.org/10.1016/j.celrep.2022.110765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615417/
https://www.ncbi.nlm.nih.gov/pubmed/35508123
http://dx.doi.org/10.1016/j.celrep.2022.110765

Ejemplares similares