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Somatostatin Receptor 4 Agonism Normalizes Stress-Related Excessive Amygdala Glutamate Release and Pavlovian Aversion Learning and Memory in Rodents

BACKGROUND: Excessive processing of aversive life events is a major pathology in stress-related anxiety and depressive disorders. Current pharmacological treatments have rather nonspecific mechanisms of action. Somatostatin is synthesized and released as an inhibitory co-neurotransmitter by specific...

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Detalles Bibliográficos
Autores principales: Adamcyzk, Irina, Kúkeľová, Diana, Just, Stefan, Giovannini, Ricardo, Sigrist, Hannes, Amport, Rene, Cuomo-Haymour, Nagiua, Poggi, Giulia, Pryce, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616361/
https://www.ncbi.nlm.nih.gov/pubmed/36324659
http://dx.doi.org/10.1016/j.bpsgos.2021.11.006