Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling

The Na-K-2Cl cotransporter-1 (NKCC1) is an electroneutral Na(+)-dependent transporter responsible for simultaneously translocating Na(+), K(+), and Cl(−) ions into cells. In human tissue, NKCC1 plays a critical role in regulating cytoplasmic volume, fluid intake, chloride homeostasis, and cell polar...

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Detalles Bibliográficos
Autores principales: Moseng, Mitchell A., Su, Chih-Chia, Rios, Kerri, Cui, Meng, Lyu, Meinan, Glaza, Przemyslaw, Klenotic, Philip A., Delpire, Eric, Yu, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616490/
https://www.ncbi.nlm.nih.gov/pubmed/36306358
http://dx.doi.org/10.1126/sciadv.abq0952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616490/
https://www.ncbi.nlm.nih.gov/pubmed/36306358
http://dx.doi.org/10.1126/sciadv.abq0952

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