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Temporal Pattern of Neuroinflammation Associated with a Low Glycemic Index Diet in the 5xFAD Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is associated with brain amyloid‐β (Aβ) peptide accumulation and neuroinflammation. Currants, a low glycemic index dried fruit, and their components display pleiotropic neuroprotective effects in AD. We examined how diet containing 5% Corinthian currant paste (CurD) administ...

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Autores principales: Dafnis, Ioannis, Mountaki, Christina, Fanarioti, Eleni, Mastellos, Dimitrios C., Karvelas, Michalis, Karathanos, Vaios T., Tzinia, Athina, Dermon, Catherine R., Chroni, Angeliki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616770/
https://www.ncbi.nlm.nih.gov/pubmed/36175825
http://dx.doi.org/10.1007/s12035-022-03047-3
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author Dafnis, Ioannis
Mountaki, Christina
Fanarioti, Eleni
Mastellos, Dimitrios C.
Karvelas, Michalis
Karathanos, Vaios T.
Tzinia, Athina
Dermon, Catherine R.
Chroni, Angeliki
author_facet Dafnis, Ioannis
Mountaki, Christina
Fanarioti, Eleni
Mastellos, Dimitrios C.
Karvelas, Michalis
Karathanos, Vaios T.
Tzinia, Athina
Dermon, Catherine R.
Chroni, Angeliki
author_sort Dafnis, Ioannis
collection PubMed
description Alzheimer’s disease (AD) is associated with brain amyloid‐β (Aβ) peptide accumulation and neuroinflammation. Currants, a low glycemic index dried fruit, and their components display pleiotropic neuroprotective effects in AD. We examined how diet containing 5% Corinthian currant paste (CurD) administered in 1-month-old 5xFAD mice for 1, 3, and 6 months affects Aβ levels and neuroinflammation in comparison to control diet (ConD) or sugar-matched diet containing 3.5% glucose/fructose (GFD). No change in serum glucose or insulin levels was observed among the three groups. CurD administered for 3 months reduced brain Aβ42 levels in male mice as compared to ConD and GFD, but after 6 months, Aβ42 levels were increased in mice both on CurD and GFD compared to ConD. CurD for 3 months also reduced TNFα and IL-1β levels in male and female mouse cortex homogenates compared to ConD and GFD. However, after 6 months, TNFα levels were increased in cortex homogenates of mice both on CurD and GFD as compared to ConD. A similar pattern was observed for TNFα-expressing cells, mostly co-expressing the microglial marker CD11b, in mouse hippocampus. IL-1β levels were similarly increased in the brain of all groups after 6 months. Furthermore, a time dependent decrease of secreted TNFα levels was found in BV2 microglial cells treated with currant phenolic extract as compared to glucose/fructose solution. Overall, our findings suggest that a short-term currant consumption reduces neuroinflammation in 5xFAD mice as compared to sugar-matched or control diet, but longer-term intake of currant or sugar-matched diet enhances neuroinflammation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12035-022-03047-3.
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spelling pubmed-96167702022-10-30 Temporal Pattern of Neuroinflammation Associated with a Low Glycemic Index Diet in the 5xFAD Mouse Model of Alzheimer’s Disease Dafnis, Ioannis Mountaki, Christina Fanarioti, Eleni Mastellos, Dimitrios C. Karvelas, Michalis Karathanos, Vaios T. Tzinia, Athina Dermon, Catherine R. Chroni, Angeliki Mol Neurobiol Article Alzheimer’s disease (AD) is associated with brain amyloid‐β (Aβ) peptide accumulation and neuroinflammation. Currants, a low glycemic index dried fruit, and their components display pleiotropic neuroprotective effects in AD. We examined how diet containing 5% Corinthian currant paste (CurD) administered in 1-month-old 5xFAD mice for 1, 3, and 6 months affects Aβ levels and neuroinflammation in comparison to control diet (ConD) or sugar-matched diet containing 3.5% glucose/fructose (GFD). No change in serum glucose or insulin levels was observed among the three groups. CurD administered for 3 months reduced brain Aβ42 levels in male mice as compared to ConD and GFD, but after 6 months, Aβ42 levels were increased in mice both on CurD and GFD compared to ConD. CurD for 3 months also reduced TNFα and IL-1β levels in male and female mouse cortex homogenates compared to ConD and GFD. However, after 6 months, TNFα levels were increased in cortex homogenates of mice both on CurD and GFD as compared to ConD. A similar pattern was observed for TNFα-expressing cells, mostly co-expressing the microglial marker CD11b, in mouse hippocampus. IL-1β levels were similarly increased in the brain of all groups after 6 months. Furthermore, a time dependent decrease of secreted TNFα levels was found in BV2 microglial cells treated with currant phenolic extract as compared to glucose/fructose solution. Overall, our findings suggest that a short-term currant consumption reduces neuroinflammation in 5xFAD mice as compared to sugar-matched or control diet, but longer-term intake of currant or sugar-matched diet enhances neuroinflammation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12035-022-03047-3. Springer US 2022-09-29 2022 /pmc/articles/PMC9616770/ /pubmed/36175825 http://dx.doi.org/10.1007/s12035-022-03047-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Dafnis, Ioannis
Mountaki, Christina
Fanarioti, Eleni
Mastellos, Dimitrios C.
Karvelas, Michalis
Karathanos, Vaios T.
Tzinia, Athina
Dermon, Catherine R.
Chroni, Angeliki
Temporal Pattern of Neuroinflammation Associated with a Low Glycemic Index Diet in the 5xFAD Mouse Model of Alzheimer’s Disease
title Temporal Pattern of Neuroinflammation Associated with a Low Glycemic Index Diet in the 5xFAD Mouse Model of Alzheimer’s Disease
title_full Temporal Pattern of Neuroinflammation Associated with a Low Glycemic Index Diet in the 5xFAD Mouse Model of Alzheimer’s Disease
title_fullStr Temporal Pattern of Neuroinflammation Associated with a Low Glycemic Index Diet in the 5xFAD Mouse Model of Alzheimer’s Disease
title_full_unstemmed Temporal Pattern of Neuroinflammation Associated with a Low Glycemic Index Diet in the 5xFAD Mouse Model of Alzheimer’s Disease
title_short Temporal Pattern of Neuroinflammation Associated with a Low Glycemic Index Diet in the 5xFAD Mouse Model of Alzheimer’s Disease
title_sort temporal pattern of neuroinflammation associated with a low glycemic index diet in the 5xfad mouse model of alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616770/
https://www.ncbi.nlm.nih.gov/pubmed/36175825
http://dx.doi.org/10.1007/s12035-022-03047-3
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